Updated 2012

The Human Papillomavirus Virion

Image by Angie Fox

Human papillomavirus (HPV) is the most common sexually transmited disease in the U.S. and is linked to over 95% of diagnosed cervical cancers. Our Lab focuses on replication, encapsidation and pathogenesis of HPVs.


Our research is focused on Human papillomavirus (HPV), one of the most common viruses infecting humans. HPVs are responsible for diseases of the skin and mucosa, including warts and cervical cancer. HPV-induced cervical cancer causes the death of 500,000 women worldwide, 90 percent of which are in developing countries. There are at least 15 cancer-causing HPV types.

The Angeletti laboratory focuses on three main topics relating to sexually transmitted HPVs. The first area of emphasis is in the analysis of long-term persistence of HPV. People infected with HPV can carry the virus for decades. We are investigating the viral signals that control this long-term persistence. A second area under study is the assembly of HPV capsid structures. Understanding capsid (virus) assembly can help in the development of novel vaccines. A final area of interest for the lab is the analysis of HPV types found in HIV positive patients in Zambia. As part of these studies, Dr. Angeletti’s research team is investigating the influence of HIV on HPV infection and tumorgenesis.

Members of the Angeletti Lab

(Left to Right) Dr. Peter C. Angeletti, Dr. Anisa K. Angeletti, Daraporn Pittayakhajonwut, Adam Rogers, John M Lowe, Ben T. Dake, Willie Hughes

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